But fusidic acid is a very valuable drug that is also administered systemically in combination with another antistaphylococcal antibiotic, usually flucloxacillin, as treatment of patients with severe staphylococcal infections. The nurse recorded the duration of impetigo, nature of the lesions redness, crusts, pustules, and painfulnessnumber of lesions, localisation and estimated area of lesions, body temperature, presence of regional lymphadenopathy, recent use of antibiotics, demographic data, and pre-existence of eczema.
Unblinding took place after the primary statistical analysis had been done. Results From February to November58 general practitioners reported children with impetigo. After the inclusion visit of the research nurse, children were included and randomised fig.
Outcomes Primary outcome measures were clinical cure, improvement, and size of affected area, as assessed by the research nurse, and bacterial cure after 7, 14, and 28 days.
These findings illustrate one of the problems surrounding antimicrobial resistance—namely, that patterns of resistance in one country cannot be extrapolated to those in another. Specifically, data for resistance rates to fusidic acid among S aureus isolates in the United Kingdom differ markedly from those in the Netherlands.
Assignment and masking The placebo cream, prepared by the pharmacist, did not differ in colour, smell, or consistency from the fusidic acid cream. We defined clinical cure as the complete absence of lesions or the lesions having become dry and without crusts; remaining local redness of intact skin was acceptable.
It is essential to use fusidic acid only as directed by your doctor as indiscriminate use can lead to the development of bacterial resistance. Editor—Koning et al report the results of a clinical trial that showed the efficacy of topical fusidic acid as treatment of patients with impetigo.
We randomised the patients in blocks and stratified them for presence of pre-existing eczema at the site of the impetigo. The hospital pharmacist packed the study medication in identical blank tubes with a code number according to the randomisation list. We used a forward selection procedure Wald to determine which adjusting variables entered the final multivariate model.
The size of the affected area was estimated by comparing the size of the actual lesions with a range of examples with different exactly measured areas on paper.
Our hypothesis was that fusidic acid cream would not improve the treatment effect of povidone-iodine. After two weeks and four weeks the differences in cure rates between the two groups had become smaller. Non-Dutch patients were mainly of Turkish or Moroccan origin, reflecting the distribution of the population in the catchment area.
Patients were advised to use the study cream for a maximum of 14 days or until the lesions had disappeared and to use common hygienic measures cutting nails short, use of personal towels.
We defined improvement as a decline in affected area, number of lesions, or both. In most cases therapy may be continued, however if the reaction is severe treatment should be stopped and the cream or ointment rinsed off.
General practitioners were free to prescribe other treatment such as oral antibiotics if the impetigo worsened or did not improve, but they were encouraged to comply with the study protocol for at least the first week.STUDY REPORT A COMPARISON OF FUSIDIC ACID CREAM (FUCIDIN CREAM) AND MUPIROCIN OINTMENT CBACTROBAN) OINTMENT IN FACIAL IMPETIGO Facial impetigo is a common problem in general practice.
Topical fusidic acid (sodium fusidate) and mupirocin have been compared previously in patients with superficial skin sepsi~.~.~ Collins et ~1.~ found that, overall, both antibiotics were of equal clinical efficacy. Jun 08, · In Nottingham the topical use of fusidic acid cream alone or in combination with topical steroids for impetigo and eczema has increased, but this has been associated with a rise in the rate of resistance to fusidic acid in S aureus isolates, particularly from cases of impetigo.
Jan 26, · Fusidic acid is an antibiotic that has been available for a long time and is mainly used topically.
14 It is recommended as the first choice topical antibiotic in the Dutch College of General Practitioners' guidelines on the treatment of impetigo. 3 Some authors discourage the topical use of fusidic acid because of its value in systemic.
Fusidic acid 2% cream and sodium fusidate 2% ointment are topical antibiotic agents that are active against a wide range of bacteria that can be found in skin infections. The trade name in New Zealand is Foban™.
Biomedical scientists are still contesting on whether the oral route or the topical route of treatment is more efficient, yet evidence-based practice indicates that topical ointments are as effective as oral treatment of impetigo (Koning et al., ).Download